At the interface of medicinal chemistry and enzymology

We are a medicinal chemistry and enzymology research group in the Department of BioMolecular Sciences at the University of Mississippi School of Pharmacy. The research in our group focuses on rational design, synthesis, and biological evaluation of potential medicinal agents and investigation of their molecular mechanisms of action. Currently, we are working on the development of glutaminase and isocitrate dehydrogenase inhibitors for the treatment of cancer, the development of κ-opioid receptor agonists and antagonists for the treatment of pain, convulsion, drug abuse relapse, and depression, and the development of cytochrome bc1 complex inhibitors for the treatment of malaria. Organic synthesis is a primary tool for this work.

Phone:        (662) 915-2555


 Hoang Le Research Group  

- December 7, 2017: Sydney received the Student Research Fellowship Award from the School of Pharmacy for the Summer of 2018. Congratulations, Sydney!

- October 10, 2017: The U.S. utility/formal patent application on "Inactivators of Toxoplasma Gondii Ornithine Aminotransferase for Treating Toxoplasmosis and Malaria" (Serial No. 15/728,714) was filed.

- August 31, 2017: Hoang was invited to participate as a reviewer for the October meeting of the NIH Macromolecular Structure and Function A (MSFA) Study Section.

- August 17, 2017: Hoang published a paper in Biochemistry on selective targeting by a mechanism-based inactivator against PLP-dependent enzymes.

​- July 28, 2017: Sydney was selected for the Honor Society of Phi Kappa Phi UM Chapter Scholarship. Congratulations, Sydney!

- July 26, 2017: Amna received the Underrepresented Minority Fellowship from the graduate school. Congratulations, Amna!

- July 5, 2017: Dr. Imran Hossain joined us as a postdoctoral fellow. He receives support from the Japan Society for the Promotion of Science. Welcome, Imran!

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Hoang V. Le, Ph.D.

Department of BioMolecular Sciences

The University of Mississippi School of Pharmacy

419 Faser Hall

University, MS 38677